Global and regional left ventricular deformation evaluation with feature tracking in transthyretin cardiac amyloidosis. Comparison with echocardiographic findings

Abstract Background Diagnosis of cardiac amyloidosis (CA) is basically based on imaging techniques. Transthoracic echocardiography (TTE) crucial to raise suspicion this disease through detection the classical features. An specific left ventricular (LV) deformation pattern with apical sparing (“cherry top”) has been described speckle tracking (ST) TTE. However, there no data regarding role LV global and regional analysis new tool feature (FT) magnetic resonance (CMR) in CA. Purpose Our aim analyze concordance between ST-TTE FT-CMR. Methods Consecutive patients definitive diagnosis transthyretin (TTR) CA, DPD scintigraphy, evaluation TTE CMR were retrospectively included. volumes ejection calculated from both following ongoing recommendations. Global segmental longitudinal strain values obtained 2-, 3- 4-chambers projections TTE, while same parameters cine views using a dedicated software FT analysis. Student t-test was used compared mean measurements derived Apical index as ratio basal-mid values. Moreover, agreement established Passing-Bablok regression Results 27 (80 years-old, 88% men) TTR CA our tertiary hospital Regarding echocardiographic findings, 80% showed concentric hypertrophy low normal fraction majority (52±10%). When (Table 1), differences noted whereas basal mid higher CRM resulting different indexes. Although 42% typical “cherry top” ST analysis, only 18% detected. Consistently, decremental observed 60% 20% CMR. Concordance constant or proportional differences, meaning techniques comparable. Conclusions Among Nevertheless, discordance resulted less frequent Funding Acknowledgement Type funding sources: None.